Курс лекций по фармокологии

тест ЛЕКАРСТВЕННЫЕ СРЕДСТВА, ДЕЙСТВУЮЩИЕ  НА СИСТЕМУ ГЕМОСТАЗА

Во время коагуляционного этапа свертывания крови происходит:                                                            1)адгезия тромбоцитов                                                                                                                                   2)фибринолиз                                                                                                                                                        3)активация плазменных факторов свертывания крови.

Активация факторов свертывания крови  происходит при наличии комплекса  следующих веществ за исключением:                                                                                                                                                         1)фермент (активный плазменный фактор - протеолитический фермент)                                                 2)субстрат (профермент)                                                                                                                                                        3)активированный кофактор (V и VIII)                                                                                                                               4)тромбоциты                                                                                                                                                                    5)ионы Са (Са2+)

В субэндотелии сосудов каких тканей есть тканевой фактор:                                                                            1)кожа                                                                                                                                                                          2)кишечник                                                                                                                                                                      3)легкие                                                                                                                                                                        4)суставы.

Какой ко-фактор активирует переход фибриногена в фибрин:                                                   1)активированный фактор Стюарта – Прауэра ( Ха фактор)                                                                           2)фактор Виллебранда                                                                                                                                            3)тромбин                                                                                                                                                     4)активированный фибринстабилизирующий фактор (ХIIIа фактор).

Гемофилия связана с дефицитом  следующих факторов свертывания  крови:                                                              1) II фактор                                                                                                                                                                                    2) Х фактор                                                                                                                                                                               3) VIII фактор                                                                                                                                                                             4) ХII фактор                                                                                                                                                                               5) IХ фактор

Препаратами для лечения гиперфибирнолиза являются:                                                                              1)гепарин                                                                                                                                                                      2)этамзилат натрия                                                                                                                                                3)апротинин                                                                                                                                           4)ацетилсалициловая кислота                                                                                                                      5)транексамовая кислота

Механизм действия этамзилата натрия:                                                                                                                        1)влияет на механизм коагуляции                                                                                                                           2)влияет на фибрин                                                                                                                                                           3)влияет на уровень тромбоцитов                                                                                                                          4)стимулирует образование тромбопластина (III фактора свертывания крови)

К антиагрегантам относятся:                                                                                                                          1)ингибиторы циклооксигеназы                                                                                                      2)низкомолекулярные гепарины                                                                                                                   3)апротинин                                                                                                                                                          4)ингибиторы АДФ рецепторов                                                                                                                       5)ингибиторы IIb/IIIа рецепторов.

Оптимальными дозами для достижения антиагрегантного эффекта ацетилсалициловой кислоты являются:                                                                                                                                                                                      1)1000-1500 мг/сут                                                                                                                                                                   2)50-70 мг/сут                                                                                                                                                                                          3)75-325 мг/сут                                                                                                                                                                   4)500-750 мг/сут

Начало заметного угнетения  агрегации тромбоцитов после  нагрузочной дозы клопидогреля 300-600 мг возникает в течении:                                                                                                                                             1)30 минут после приема нагрузочной дозы                                                                                                                 2)60 минут после приема нагрузочной дозы                                                                                                                   3)90 минут после приема нагрузочной дозы                                                                                                              4)120 минут после приема нагрузочной дозы                                                                                                                               5)150 минут после приема нагрузочной дозы

Рекомбинантным тканевым активатором плазминогена является:                                                1)стрептокиназа                                                                                                                                                     2)урокиназа                                                                                                                                                             3)алтеплаза

Наличие повышенного уровня Д-димера в коагулограмме указывает на:                                         1)активацию сосудисто-тромбоцитарного звена гемостаза                                                                          2)наличие активного воспалительного процесса                                                                                                        3)на формирование фибрина и лизис фибринового сгустка

Из какого сырья добывают нефракционированный гепарин:                                                                        1)слизистая кишечника свиней                                                                                                                                         2)бычьи легкие                                                                                                                                                                         3)почки крупного рогатого скота

Основной мишенью антитромбина III являются следующие факторы свертывания крови:  1)фибриноген                                                                                                                                                                                                                  2)тромбин                                                                                                                                                                                 3)Ха фактор                                                                                                                                                                              4)ХIа фактор                                                                                                                                                                 5)IХа фактор

Связывание с каким плазменным белком обеспечивает антикоагулянтное действие гепарина:  1)антитромбин III                                                                                                                                               2)плазминоген                                                                                                                                                      3)протрмбин

Гепарин с молекулярной массой менее 5400 Да:                                                                                                              1)не ускоряют инактивацию тромбина                                                                                                                                                                      2)ускоряют инактивацию тромбина                                                                                                                                3)не ускоряют инактивацию Ха фактора                                                                                                           4)ускоряют инактивацию Ха фактора

Прямым ингибитором Ха фактора  являются:                                                                                                    1)гепарин                                                                                                                                                         2)фондапаринукс натрия                                                                                                                              3)ривароксабан                                                                                                                                                   4)добигатран                                                                                                                                                         5)варфарин                                                                                                                                             6)ацетилсалициловая кислота

Прямым ингибитором тромбина являются:                                                                                                       1)гепарин                                                                                                                                                         2)фондапаринукс натрия                                                                                                                             3)ривароксабан                                                                                                                                                           4)добигатран                                                                                                                                                           5)варфарин                                                                                                                                             6)ацетилсалициловая кислота