Leonardo da Vinci

Growing up in his father's home, Leonardo had access to scholarly texts owned by family and friends. Even as an apprentice, Leonardo demonstrated his colossal talent.
His handwriting is amazing, he wrote from right to left, the letters are reversed so that the text easier to read using a mirror
In an era when left-handedness was considered the devil's work and lefties were often forced to use their right hand, Leonardo was an unrepentant southpaw. It has been suggested that this "difference" was an element of his genius. He even wrote backwards, and his writings are easily deciphered only with a mirror.